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The ability of HCF proteins to stabilize this VP16-induced complex has been conserved in diverse animal species including Drosophila melanogaster and Caenorhabditis elegans suggesting that VP16 targets a conserved cellular function of HCF-1.
Mitochondrial respiration is an important and widely conserved cellular function in eukaryotic cells.
The broad expression pattern suggests a conserved cellular function for mouse RNase III.
Finally, it is striking that, despite its highly conserved cellular function, centromeres evolve so rapidly.
These results support the hypothesis that Pls1 tetraspanins are involved in a conserved cellular function essential for appressorium function.
The genetic resource can be utilized to further our understanding of essential gene function and will be applicable to the study of C. elegans development, conserved cellular function, and ultimately lead to improved human health.
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Autophagy and phagocytosis are conserved cellular functions involved in innate immunity.
Altogether, these characteristics suggest that sRk11, sRk28 and sRk33 might have conserved cellular functions in the Thermococcales.
Thus, genes encoding basic and highly conserved cellular functions are no less likely to be alternatively spliced than are other genes (for instance those involved in multicellularity or other complex functions).
Our results confirmed that a select group of genes associated with the establishment of cell polarity, bipolar budding, and cell separation were significantly altered, suggesting that low-shear conditions alter yeast gene expression in evolutionarily conserved cellular functions such as cell polarization [ 13].
(1) There are a number of conserved cellular mechanisms involved in numerous cellular functions that are also permissive for biological oscillations in the frequency range of hours.
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