Exact(19)
Biosynthesis of glycosylphosphatidylinositol (GPI) anchor in the endoplasmic reticulum (ER) of the cell represents a highly conserved activity in eukaryotes due to the conservation of the basic structural unit of GPI anchors [ 1, 2].
Significant advances in understanding the molecular basis of Cif activity have recently been made with the demonstration of conserved activity in cell-based assays for all known Cif family members and structural studies.
The uniforms distribution of ABC-E proteins among fungi and other eukaryotes supports the notion that they are involved in a highly conserved activity in the cell.
Here we present a strategy for the systematic identification of evolutionarily related enhancers that have a conserved activity but divergent sequences.
We have previously shown reduced activation of effector T cells by Dpg-Pol extracts compared to native allergen extracts but conserved activity of regulatory T cells [ 20].
Promoters or enhancers were considered as having conserved activity between species when their orthologous location in the second species overlapped a marked region by a minimum of 50% in length.
Similar(40)
Recent studies have advanced our understanding of the molecular mechanisms underlying these conserved activities and their integration with cellular needs.
Water conserving activities are a great family exercise: Turning off water when brushing teeth, fixing dripping faucets the moment they're noticed, washing the car on a lawn rather than on concrete, cleaning the pool regularly so that water doesn't have to be changed, etc. Minimizing waste.
Compared with controls, patients with CRF showed preserved mitochondrial content, conserved respiratory activity, intact enzyme activity of MRC complexes, and no increase in lipid peroxidation.
Maybe this protein has conserved GTPase activity and as it evolved to Rab2A (crown position) it acquired specific prenylation activity (Fig. 7c).
A Chloro substituent at the 2-position of 1a, compound 1d, retained potency against DNMT1, while N6 alkylation, compound 7a, conserved DNMT3b2 activity.
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