They are well-conserved, a-specific enzymes.
Thus, it is likely that the single His residue is highly conserved for a specific role.
Our findings demonstrate that the protein architecture is remarkably conserved within a specific subfamily.
The motifs and their arrangement in the BdWRKYs are similar among proteins within subfamilies, demonstrating that the protein architecture is remarkably conserved within a specific subfamily.
This uneven distribution of DUFs suggests that these families are more likely to be conserved in a specific organism or for specific environmental conditions and unlikely to be a part of housekeeping or constitutive proteins [ 4, 30].
We think that observed differences between OA and RA patients (5α-hydroxylation) are not specific for RA patients because, most probably, increased hormone conversion has not been evolutionarily conserved for a specific disease.
All metagenomic bioinformatics analyses were performed on Orion Integrated Bioscience servers using motif fingerprint generation (MF-gen) and CHAST algorithms to identify protein segments conserved across a specific taxonomy [ 30, 31].
The catalytic domain and their structures in the BdMAPK cascade kinases are similar among proteins within subfamilies, demonstrating that the protein architecture is remarkably conserved within a specific subfamily.
The coat protein of Sf6 is similar to that of bacteriophage P22 and is known to include surface exposed domain (a conserved feature specific to P22 like bacteriophages) with an "HK97-like" core [ 32].
By using a 14-residue fragment of CCR5 Nt containing two TYS residues, we recently showed that CCR5 Nt binds gp120 through a conserved region specific for TYS moieties and suggested that this site may represent a target for inhibitors and probes of HIV-1 entry.
Within these HEAT repeats, our studies identify a conserved Rif1 specific repeat and this might be useful in identifying the core conserved interacting partners.
