Interestingly, the dN/dS ratios in these conserved regions were low, suggesting that positive selection pressure in speG operates to conserve a function other than superantigenic activity, because none of the SDSE clinical strains expressed SpeG proteins [ 13- 15].
Whereas the B, C and E functions are regarded to be broadly conserved, the A function in specification of the perianth is not widely observed and questioned in Antirrhinum [ 52, 53], as well as other plants [ 54].
All other domains in PRDM9 are conserved among species, suggesting that a conserved biochemical function is tethered to a rapidly evolving DNA-binding specificity.
Taken together, our results further support a conserved enzymatic function of Jmjd6 most likely as a classical non-heme, Fe(II)- and 2OG-dependent dioxygenase.
Of the 177 human orthologues, 26 inhibited aggregation in the HK293 cells supporting the idea that genetic regulators identified in C. elegans would have a conserved function relevant for a human model [ 23].
The ability of HCF proteins to stabilize this VP16-induced complex has been conserved in diverse animal species including Drosophila melanogaster and Caenorhabditis elegans suggesting that VP16 targets a conserved cellular function of HCF-1.
The broad expression pattern suggests a conserved cellular function for mouse RNase III.
These results support the hypothesis that Pls1 tetraspanins are involved in a conserved cellular function essential for appressorium function.
Another example is CD50 and CD51 that carry a conserved guiding function for U24 and U24b in S. pombe, respectively.
Conversely, undefined signaling through the TLR adaptor molecule MyD88 seems to have a conserved antimicrobial function in zebrafish (van der Sar et al., 2006; Hall et al., 2009).
