Although the tertiary structure of the core serpin-fold is strongly conserved, the primary sequence constraints are relatively loose [ 1].
Most of the sites are conserved: the primary metal binding site and the putative hydrophobic channel remain before the frameshift, and only the fourth (and last) part of the catalytic network seems changed.
Despite the unique features and differences described above, all of the eubacterial and eukaryotic proton pumps conserve the carboxylic primary proton acceptor (homologous to Asp85 of BR).
Although the stem-loop secondary structure may be conserved, the corresponding primary structure, on which the HMMs work, is not as conserved.
However, UCSC genome browser found no homolog in mouse, dog and others except Rhesus (Supplementary information, Figure S4), suggesting that RoR is poorly conserved at the primary sequences, even though lncRNAs could be relatively conserved in terms of RNA secondary structures.
The hydrazine must be conserved for the primary mission at Saturn, said officials at Jet Propulsion Laboratory, which manages the mission for the National Aeronautics and Space Administration and the European and Italian space agencies.
To further validate this model, we inserted one to three Gly-Ser dipeptides (GS) between amino acid R27 and T28 of Kir6.2, a position before the structured Kir6.2 CTD and not conserved in the primary sequence (Fig. 2G), suggesting this position is not directly involved in SUR1 binding.
Although the information for protein structure is conserved at the primary amino acid sequence level, many proteins are easily misfolded in the crowded cellular milieu.
The randomised arms were conserved from the primary trial for the main analysis.
Secondary structures play a key role in the functions of ncRNAs and are more highly conserved than the primary sequences.
