Sentence examples for conserve the binding from inspiring English sources

Interestingly, we found that the co-binding peptide provided ~ 2 kcal/mol of stabilization as shown by their respective Docking Score (DS) and also proceeded to conserve the binding mode orientation of abacavir [44].

Although the SusD scaffold is structurally well conserved, the binding pockets for saccharide ligands exhibit a larger degree of plasticity [ 34, 35].

This was attributed to the reduced level of cross-linking, which is required to conserve the imprinted binding cavities during polymerization.

However, while the C. elegans sequences conserve the heme-binding histidine residue, they lack two critical cysteine residues required for NO activation in mammalian sGC β-subunits [ 28].

Although the proline-rich region is not always conserved, the SH3 binding domain is conserved in the dsh-1 orthologs of all taxa, but is absent in nematode mig-5 orthologs.

However, the seventh binding site, notated in Figure 4 as bs2, is poorly conserved and the binding site peak probabilities do not exceed 50%.

The V2 mAbs target conserved epitopes, including the binding site for α4β7 integrin, and are broadly cross-reactive with various gp120 proteins.

Although Cavarelli et al. identified three highly conserved residues in the binding pocket of yArgRS, the thermodynamic contributions of these and other surrounding residues to the overall binding affinity remain elusive.

With the p-value cutoff of 0.01, we calculated the proportion of the significantly conserved binding sites among the over-represented putative binding sites.

This is consistent with the finding that the c subunit of the F1FO ATP synthase does not have the conserved Na+ binding motif.

FTO and ALKBH5 belong to the AlkB family owing to the conserved iron binding motif and α-ketoglutarate interaction domain [51 54].