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The R340N mutant (DNA-binding mutant, DBDM) has been shown to conserve some degree of transforming capacity in NIH3T3 fibroblasts despite lacking DNA binding activity [12].
Indeed, theoretical studies in the former direction suggest that evolution of altruistic defense traits is hindered when infected hosts conserve some degree of reproductive ability [ 45].
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The adsorption target for this phage is an essential outer membrane protein, BamA, which is involved in the biogenesis of the Gram negative bacterial outer membrane and is not only highly conserved across members of the Enterobacteriaceae, but also conserved to some degree in all Gram negative bacteria [ 20].
"We are still awaiting the final reports from the survey, but we are delighted that the majority of the pieces making up the intricate metal lanterns from the iconic light fitting have been found along with books from the rare book collection which can be conserved to some degree, parts of the studio clock and of the original library chairs and periodicals desk.
Pseudogenes that are conserved to some degree and are not lost at such large evolutionary distances are interesting and could be suggestive of functionality.
The higher component specificity of biochemical and catalytic-chemical conversion has the attraction over thermochemical conversion of conserving to some degree the components requiring more solar energy for biosynthesis.
Nonetheless, the large/small particle ratios for the mouse nascent HDL increased with the transition from the low to high available cell lipid:apoAI ratio (Fig. 10 B), indicating that structural features responsible for the genesis of nascent HDL particle heterogeneity are conserved to some degree between human and mouse apoAI.
The sux CUT locus seems less well conserved and showed some degree of variation (Figure S2D).
The higher divergence in intron 3 compared to exon 3 among the iguanine UA sequences suggests that this gene is conserved and under some degree of purifying selection, or at least is not evolving neutrally as would be expected for a nonfunctional pseudogene.
The deletion of αSNAP is embryonically lethal in mice [13]; hence the M105I mutant must conserve a certain degree of functionality for intracellular transport and regulated exocytosis, but cannot support acrosomal exocytosis.
In addition, studying tumors after various passages in vivo showed that these models conserve a high degree of genomic and gene expression stability over time.
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