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This strategy was based on the idea that interlinked genetic markers (or brain ROIs) would conserve similar expression pattern, i.e., would be highly co-expressed.
Previously, the FFL motif conservation has been shown to correlate with the lifestyle defined as a set of several parameters like oxygen requirements, optimal growth temperature, environmental condition and pathogenicity, so that organisms that share a similar lifestyle tend to conserve similar transcriptional regulatory network motifs [ 27].
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Ala et al. (2008) systematically integrated human mouse conserved similar expression profiles with phenotype similarity map to rank potential disease genes in large genomic regions.
Various distance methods have been employed to compare and align relatively conserved similar sequences [5], [7], [8].
Some miRNA* strands might become functional guide strands and they were phylogenetically conserved similar to their mature miRNAs.
Other miRNA* sequences were well conserved similar to mature miRNAs, such as miR-18a*, miR-18b*, miR-17-3p miR-455-3p miR-455-3p miR-455-3p
As Aret and its sarcomeric targets are evolutionarily conserved, similar principles may regulate mammalian muscle morphogenesis.
The overall organization of the caecilian Hox clusters was conserved, similar to those from other species with four clusters.
Residues were classified as invariant (identical in all sequences), highly conserved (similar in ≥90% of sequences), semiconserved (similar in ≥80% of sequences), or nonconserved.
Differentiated cells (shifted to serum-containing medium) conserved similar expression profiles of all the markers, with the remarkable exception of CD44, which was undetectable after differentiation.
After identifying all contact positions in CCT monomers, we distinguished among them those that conserved similar amino acid types across the nine monomers.
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