Wnts are evolutionarily conserved major regulatory factors in both development and disease.
In Figure 8B, we focus on genes containing at least one conserved major site, as a surrogate for sites existing prior to human-mouse divergence.
Therefore, we examined if specific types of fiber tracts were preferentially affected, which might be conducive to conserving major topological features.
PARP-1 consists of three conserved, major domains, a NH2-terminal DNA-damage sensing and binding domain containing three zinc fingers, an automodification domain, and a C-terminal catalytic domain.
Macroautophagy is a highly conserved major cytoplasmic degradation pathway of eukaryotic cells, which, in contrast to the ubiquitin proteasome system, can engulf protein aggregates and organelles in a double-membrane vesicle.
Since C. jejuni strains express the conserved major fibronectin-binding protein CadF [ 15, 17, 18, 20] and because fibronectin is the natural ligand for integrin-β1 receptor [ 59, 60], our current findings indicate a cascade of fibronectin→integrin-β1→FAK/Src-dependent signaling events occurring during infection.
Last June it announced an ambitious collaboration with WWF, a global environmental organisation, to conserve seven major freshwater river basins.
While there are some short functional sequence motifs located in the 3'UTRs that are conserved, the major part of the 3'UTRs sequences has revealed a much lower conservation level than coding sequences.
The N-terminal 14 residues of AscE, PscE and YscE are highly conserved (a major homology region) (Fig. 1A).
To our knowledge, the only molecular information available on STIV mainly concerns the highly conserved STIV major capsid protein.
