Nevertheless, many related proteins show conserved functionality more in terms of domain and structural conservation.
oryzicola after transfer to rice, suggesting conserved functionality across different genera of grasses.
The analysis based on the conservation of individual binding sites, however, does not address the question whether a promoter or enhancer, which typically have multiple binding sites, would have conserved functionality or not, as the gains and losses of binding sites in the neighborhood may compensate each other so that the overall affinity remains largely unchanged [56], [64], [65].
The sequence homology may result from conserved functionality.
The biological alterations in humanized AVPR1A mice resulted in the rescue of the prepulse inhibition impairments that were observed in knockout mice, indicating conserved functionality.
We shared the initial concern with reviewer 2, which is the reason why we validated the structural models and demonstrated conserved functionality in great detail and at several levels.
Disruption of ScEss1 can be complemented by DmDodo [ 21] and the plant Digitalis lanata's Par13 [ 107], which lacks the WW domain conserved in the other proteins, indicating a conserved functionality may exist between all Pin1 orthologues that is essential in some but not all organisms under normal growth conditions and only requires the rotamase domain.
It has the advantage of offering a strongly regulated in vitro environment, while preserving much of the complex cellular integrity, including cellular barriers and intact circuitry, and as a result conserving functionality – resulting in an in vitro environment more comparable to the in vivo brain than seen in the homogenate method.
These findings indicate that the self-renewal of reset human cells, but not conventional PSC, is strongly reliant on TFCP2L1 and KLF4 and furthermore point to conserved functionality of ground-state transcription factors between mouse and human, even though individual factor expression may be altered.
This suggests an explanation for their high abundance in genomic regions and low abundance in coding regions, which must be conserved to maintain functionality.
