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Function recognition is further complicated by protein-protein interactions, multimeric functional states, paralogous sequences that often do not conserve function, or the multifunctional nature of few proteins [ 50– 50].
For one entity to be a copy of another, it must be the output of a process whose biofunction is to conserve function.
When aaPSEC = 0, this is the evolutionarily most common allele (inferred to be definitely functional), whereas more negative values of aaPSEC indicate that the allele is less likely to be observed across evolution (inferred to be less likely to conserve function).
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As noted previously [ 17], the conservation of coexpression clusters can provide an even more powerful indicator of likely conserved function.
Conserved patterns of DAX1 gene expression from mammals to fish have been taken to suggest conserved function.
NS and PRS show conserved function during the recruitment of organ founder cells from the lateral domain of plant meristems (Nardmann et al.[2004]).[2004]
The mosquito TEPs have been found to possess conserved function, which results in the phagocytosis of bacteria (Shokal and Eleftherianos, 2017).
Despite this, there is a family of DM-domain transcription factors (Dmrts), which hold a highly conserved function in sexual development.
But here's an interesting thing about the 'Just-in-Time' brain: Memory is a highly conserved function, which we all know behaves like a muscle in a use-it-or-lose-it kind of way.
The orthologs predicted by OrthoMCL often exhibit conserved function.
This similarity suggests related and conserved function(s) [12].
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