This enzyme functions as a zinc metalloprotease and is highly conserved, and it was discovered by its ability to complement the homologous function in yeast (Tam et al. 1998).
In summary, our result clearly showed SaSTT3A was functionally conserved and it might have the similar function in N-glycosylation.
Interestingly, s5 is highly conserved and it is never followed by a proline in positon (N+3) in TRP1 and TRP2, confirming the importance of this site for the other two members of the family rather than for tyrosinase itself [8].
The D' box is much less conserved and it varied from CUGA to CAGA, UUGA, AUGA, ACCA and CCGA.
The amino-terminal 'tail' of each histone is evolutionarily conserved and it is target of numerous post-transcriptional modifications.
STI1 is widely conserved and it has been found in diverse organisms; however, it is named differently depending on the organism.
In mammals, INSC is functionally conserved and it is required for correct orientation of the mitotic spindle in retina [ 43] and skin [ 44] precursor cells.
The synteny of Osiris genes in flies is well conserved, and it is one of the largest syntenic blocks in the Drosophila group.
Mitochondrial fragmentation is one of early events that occur in apoptotic pathway, it is evolutionarily conserved, and it represents a clear hallmark of mitochondrial perturbation, which precedes effector caspase activation and cell death.
The TM domains of the IgD, part of the IgD-BCR on the B cell surface, are evolutionarily highly conserved and it has been shown that they are involved in the oligomerization of this receptor [94,95].
The regions of the actin molecule that are involved in F-actin assembly are largely conserved, and it is likely that mammalian actin is able to incorporate into microfilaments in plant cells but there is no experimental evidence until now.
