Conservatively, sample size determination was based on the stratified model, with the requirement of at least five subjects per parameter to be estimated in covariance structure modeling [ 19, 20].
This filter conservatively removes size differences that could be explained by errors in determining the length of homopolymer runs, which can be a substantial problem in 454 sequencing data.
Small sized, well-contained perforations are common in the course of the disease and most cases can be managed conservatively with antibiotics and supportive medical treatment.
33– 36 Because of this tendency, we measured diarrheal disease prevalence conservatively, and therefore, the effect sizes given in this study are likely underestimates.
However they can be approximated by physical positions (NCBI Build 35, May 2004) of the probe pairs having the maximal distance within a CNV, yielding conservatively shorter defined sizes of CNVs than the actual sizes.
Secondary pneumothoraces are only treated conservatively if the size is very small (1 cm or less air rim) and there are limited symptoms.
In the absence of data relating to change in HbA1c we have calculated sample size conservatively based on the absolute level of HbA1c at follow up.
Using 80% of the effect size observed in two previous placebo-controlled phase II studies (NCT00618722 and NCT00618618) and a 10% dropout rate per treatment group with a Pearson chi-square test for two proportions (two-sided test with α = 0·025), we determined a conservatively rounded sample size of 120 patients per treatment group to guarantee a power of 90%.
In view of the sample sizes available to us we decided to conservatively categorise STUs into two sexual systems, gonochoric and androdioecious.
While effect sizes for some structural components are small, Europe has a population of over 802 million and if we assume conservatively that 2% of men aged 15 65 are MSM, the potential public impact on 5.35 million MSM is considerable.
