Sentence examples for conservative toxicity from inspiring English sources

The ingestion RfD provided a conservative toxicity end point because it typically was based on the most sensitive NOAEL.

While effect definitions that do not account for potential compensatory reactions will probably lead to more conservative toxicity estimates at the screening level, this is in agreement with the precautionary principle that the burden of proof that it is not harmful falls on those taking action.

While it cannot be inferred that this is true for all possible biological endpoints, the currently available data suggest that air-liquid interface exposures are a more "conservative" toxicity test than submerged systems, that is, ALI cell systems are likely to lead to less false negatives.

Therefore, for conservative estimation of toxicity risk, a 12-µg/ml threshold was used for Cmax in this study.

Therefore, chronic human health values were used in this assessment as conservative estimates of acute toxicity RVs.

In the case of human health assessments, Cramer classes provide an alternative source of conservative estimates of oral toxicity [2, 9].

In addition, the assessment with this data set is expected to be more conservative, because the lowest toxicity measures (median effect (lethal) concentration, E(L C50, and no-observed-effect-concentration, NOEC) within each of the six endpoints are used for the prediction.

NC was selected to pair with the toxicities as opposed to PR given that this is a more conservative approach; if the toxicities were coupled with PR, for example, it is possible that respondents would not rate them as poorly as they would if they were coupled with NC because they may be more accepting of an aggressive therapy if they know that the treatment is working.

To be conservative in the assessment of toxicity as a consequence of two episodes of hyperbilirubinemia, two additional patients were enrolled into this first cohort without any DLT.

Even the more conservative approach of combining the lowest toxicity values within each of the six endpoints for the mixture toxicity predictions (as exemplified with the second data set) resulted in a more than 100-fold underestimation of product toxicity in 0% to up to 9% of cases.

Radiation therapy is commonly used to treat localized prostate cancer; however, representative data regarding treatment-related toxicities compared with conservative management are sparse.