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All factors were in the range 1.0 to 2.1, below the conservative threshold for collinearity.
The low rate of correct classification was caused by our conservative threshold for identifying patients with anticipated death.
Cluster analysis yields 11 different branches above our conservative threshold for the 19 distinct GIs and the two chromosomes.
Using this conservative threshold for isoform abundance gives a lower-bound estimate of the fraction of alternatively spliced NAGNAG sites.
We tentatively selected a two-fold (or greater/lesser) criteria (relative to control values) to be a conservative threshold for measuring alterations in gene expression.
This allowed us to determine a conservative threshold for CNVR identity, with what we considered an acceptable FDR of 11%% [ 41].
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Additionally, if more conservative thresholds for support were favored, this would also tend to require the use of more loci.
Using conservative thresholds for differential gene expression, we identified 231 transcripts differentially expressed in cells treated with 1% bovine serum albumin (BSA) versus control conditions for 6 hours.
In all these searches, applying conservative thresholds for model inclusion tended to cause abrupt decomposition of the pathways into small fragments, typically representing stoichiometric subunits of the enzymatic complexes (data not shown), in agreement with our earlier observations made using hierarchical clustering [3].
Moreover, we extrapolated data from hospital-based studies and used conservative thresholds for the diagnostic tests.
Given the large genome size and potential for spurious annotations, conservative thresholds for these filters were chosen.
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