The e-mail's potential for political embarrassment lay partly in what it suggested about the Conservatives' sensitivity to the mood of Mr. Murdoch and his son James, who until earlier this year was the principal overseer of the Murdoch media properties in Britain.
Use of the CPI to index reported costs to 2012 US funds controlled for realistic cost increases over time, and led to an average index rate of 4.2% per annum, only slightly higher than the conservative sensitivity analysis index rate of 4.0%.
That choice was pursued with a conservative sensitivity analysis, including all growth models, to assess the uncertainty of estimates of parameters describing cell kill and resistance.
Furthermore, estimates of infection prevalence are likely to be conservative, as the sensitivity of our PCR screen may miss Drosophila with low Spiroplasma titer.
For conservative purposes, to preserve sensitivity of detecting nearly all cases, low cut-off levels were employed: 3×ULN for ALT and 2×ULN for TBL.
Robin Hicks, a cultural anthropologist at Ball State University in Muncie, Ind., said that when the kissing involves people of different ethnicities — especially a Western man and a local woman, as in the case of Mr. Gere's kiss in India — the cultural sensitivity of conservative-minded people is often greatly heightened.
We chose this conservative approach to test the sensitivity of the effect estimates under a broad range of model assumptions.
Given the conservative prevailing culture and the sensitivity of the topic, this difficulty is understandable, yet talking to males – who are the sole decision-makers in the patriarchal system of society – is vitally important.
Indeed, to measure a sensitivity of 87% (conservative estimation based on both local studies: 89% in 2001 13 and 87% in 2012 15) with a precision of 5% (half-CI of sensitivity lower than 5%), with an α risk of 5% and a rejection prevalence of 30% (estimation based on both local studies with a similar design), the sample size should be 580 MRI-biopsy couples.
- A conservative estimate of the typical minimal sensitivity of detection of methylation by the relevant assays might be 20% for direct bisulfite sequencing, 10% for pyrosequencing and 15% for Infinium analysis.
