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Current doses provide a conservative risk reduction and some individuals demonstrate 'aspirin non-responsiveness', with insufficient antiplatelet effects.
Using the more conservative risk reduction estimates based on 2000-6, westimatethathat 20 mph zones prevent 203 casualties each year, of whom 27 would be killed and seriously injured and 51 would be pedestrians.
This is a more conservative risk reduction than that found in the trial by Kiss [ 14], where analysis of this subgroup suggested treatment of asymptomatic candidiasis was associated with a 65% reduction in spontaneous preterm birth but the numbers were small and the subgroup analysis was post-hoc.
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In our model, we assumed that diagnosing cGDM and iGDM in pregnancy could reduce the likelihood of developing diabetes by the more conservative diabetes risk reduction of 34%.
Based on these data, a conservative expected relative risk reduction of adjuvant HIPEC is 60%%.
Given that the incremental incidence of sexual assault declines over time we estimate, for the purpose of sample size calculations, the 1-year rates to be 25% in the brochure arm and 17.5% in the educational program arm; a more conservative 30% relative risk reduction.
Because our patients were already hypertensive at study entry and had other risk factors, we considered a conservative assumption of 60% risk reduction as appropriate.
This was not done for comparators, again following a conservative approach, since risk reductions for this specific population were either not reported or lower than that in the overall population (Table 1).
This was a conservative estimate in comparison with the pooled risk reduction of 63% calculated from six previous studies of household filters[8].
Data from the systematic review of CTG + FBS trials and observational data from Australian hospitals support a conservative estimate of up to a 40%% relative risk reduction in caesarean sections when FBS is added to CTG monitoring [ 12, 27, 28].
We considered a conservative and an optimistic benefit of 30 and 40% risk reduction respectively.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com