Sentence examples for conservative replacement of from inspiring English sources

The YbdB sequence alignment reveals high conservation of Met68 and Thr15 and conservative replacement of Phe71 (with Tyr or Trp).

Valine is a conservative replacement of isoleucine.

These steroid receptors contain corresponding arginine and phenylalanine residues, and a glutamine, which is a conservative replacement of glutamic acid.

Valine is a conservative replacement of Ile and would have similar van der Waals contacts with 15α-OH-E2, in contrast to the hydrogen bond between Sδ on Met-409 in lamprey ER and 15α-OH-E2.

While the conservative replacement of tyrosine (QPQLPY) with phenylalanine (QPQLPF) did not drastically reduce the affinity of the G12 moAb, substitution with leucine (QPQLPL) reduced the affinity a thousand-fold, indicating the importance of this last position in determining affinity.

Lamprey CR contains a threonine, which is a conservative replacement of serine.

First, highly conservative replacements of exterior residues, none of which would cause significant functional disruption alone, are combined until roughly one in five have been changed.

We repeated the same procedure using exchange groups, which represent conservative replacements of AAs through evolution (Dayhoff et al. 1978).

More conservative replacements of the benzyl with pyridylmethyl groups afforded active compounds, especially for the 2- and 3-pyridylmethyl analogues 5c and 5d, whereas the 4-pyridylmethyl isomer 5e was less active.

503 of these lead to a non-conservative replacement of an amino acid as defined by a Dayhoff similarity index [ 22] of less than 5 (Additional file 2).

The GHR polymorphism studied here is an A to T substitution in exon eight of the gene which results in a non-conservative replacement of phenylalanine with a tyrosine residue (F279 Y) [ 42].