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We chose the most conservative findings with the lowest effect size (Cappy's 3-month change: d = 0.65) for the sample size calculations.
It is not possible to determine the extent to which this may have affected the results; under-reporting of suicidal behaviours would contribute to more conservative findings.
However, one of the model's simplifying assumptions was perfect compliance and this is expected to have led to more conservative findings.
25 Follow-up rates were high, and we did not impute missing results (which would provide even more conservative findings than this analysis so would not alter the inferences).
Using a comparison group from the same population increases the homogeneity of the sample and ensures conservative findings (that is, a bias toward the null), particularly if there is a healthy survivor effect that reduces the frailty of those who survived among the infection groups versus those who survived among the controls.
For both cognitive decline and dementia, studies reporting ORs, RR 0.67 and RR 0.89, studies of high quality, RR 0.73 and RR 0.87, with a greater number of adjustments (≥10), RR 0.68 and RR 0.86, and longer follow-up time (≥10 years), RR 0.89 and RR 0.86, respectively, provided more conservative findings.
Similar(54)
But, he cautions, judges are conservative, finding it "very difficult to change their minds".
"The conservative finding is that solenodons, traditionally thought to be a recent divergence of a lineage of insectivores, are actually much more distantly related to that group than we expected," Dr. O'Brien said.
When a reporter asked if the recent rise in support for Rick Santorum, a former senator from Pennsylvania, had to do with social conservatives finding him the more electable candidate, she said Iowans should not pay attention to polls or a candidate's stature so much as character.
This is about conservatives finding a soft scandal to drive news coverage and yet another round of fundraising.
Although the range was skewed (no one identified as extreme conservative), the finding that extreme liberals don't find evolution applicable is not new (Richards 2008).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com