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Each scenario was evaluated using a conservative efficacy rate (4 percent) and an optimistic efficacy rate (23 percent) of averted mortality, and results were obtained for the number of DALYs and deaths averted over a 20-year time frame.
The main efficacy analyses were performed 'per started cycle' (i.e. including all subjects who started treatment regardless whether they discontinued) as this provides the most conservative efficacy estimates as it also accounts for any unintended interference of premature cycle cancellations.
Similar(58)
Therefore, conservative estimates of efficacy over 12 months were based on published reports from trials among high-risk methamphetamine users in the U.S. using a similar brief behavioral intervention [11].
Analysis of the CZP ITT population gave a more conservative estimate of efficacy, with ACR20/50/70 response rates of 59.0%, 43.7% and 28.8%, at week 256.
By assessing 12-week time periods where all complications are considered as a single occurrence, the SMPR avoids multiple counting of events, and therefore represents a conservative measure of efficacy.
The two methods are similar, and both slightly conservative for higher efficacies; the log link slightly more so.
For μ0 = 0.1 and 0.05, the pattern is similar to the smaller Poisson means, with both being slightly conservative for higher efficacies; the logit link slightly more so (not shown).
To describe the efficacy of conservative management of retinoblastoma by an association of conservative ocular therapies and chemothermotherapy.
In Beecher's study, this might have been missing, because the dispenser of the drug would have known that the drug might just be a sugar pill – so this 35% may be a conservative estimate of the efficacy of placebo.
To evaluate the efficacy of conservative laparoscopic treatment of genital prolapse in women of reproductive age.
The primary endpoint was defined as the efficacy of conservative treatment and EA to lower IAP in patients with IAH and ACS.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com