A more conservative dose of 60 units/kg loading dose and 12 units/kg/h maintenance dose is thus chosen for patients with severe kidney dysfunction.
Therefore, a conservative dosing of UFH is recommended in patients with severe renal impairment to avoid supra-therapeutic anticoagulation [ 18, 19].
The relatively conservative dosing of cisplatin (75 rather than 100 mg m−2) and 5-FU (4 rather than 5 days) was an attempt to limit the risk that chemotherapy-induced toxicity might delay the start of chemo-radiotherapy, which is considered to be the most important curative component of the treatment approach.
Higher GMFCS levels (IV,V) and higher doses of BoNT-A were associated with increased incidence of adverse events, leading the authors to recommend conservative dosing for children classified GMFCS IV-V [ 29].
Similarly, more conservative doses are expected to carry less risk of breast cancer than full-dose H.R.T., but it could take decades to determine this.
Important age-related factors, as well as the pharmacokinetics of aripiprazole (eg, longer elimination half-life), dictate the need for conservative dosing; the avoidance of polypharmacy when possible; careful monitoring for the development of adverse events and/or drug interactions; and more careful titration and tapering strategies.
HFSRT with conservative total doses of no more than 30 Gy is safe and leads to similar OS times as more aggressive treatment schemes.
In addition, as suggested by the sponsor, the modest differences seen in serum sodium may have been partially a result of a conservative dose titration scheme.
However, the conservative dosing regimen adopted at the start of deferasirox treatment meant that overall median serum ferritin levels did not decrease below baseline during the first 2 years, when the average actual dose was <20 mg/kg per d.
Additional precautions for older adults recommend "conservative" dosing, and to only start metformin in adults ≥80 years of age if creatinine clearance is normal [ 8, 9].
