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These conservative correlations can be used in the design of in-vessel core catcher in pool-type SFR in order to ensure safe retention of radioactivity within the primary containment system even under whole core accident scenarios (WCA).
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Missing information may reflect a negative or more conservative correlation between markers and survival, which could lower the significance of markers expression as a predictor of mortality [ 141].
We approximated paired analyses for the one cross-over trial using a conservative correlation coefficient (0·5) with sensitivity analyses at 0·25 and 0·75.
Assuming a conservative correlation of 0.5 implied that the sample size could be reduced by 25%, and still maintains the same power.
Based on a moderated and conservative correlation (r = 0.4, effect size) and using α = 0.05, β = 0.20, and power = 80%, approximately 37 subjects were needed for this study [ 23].
Including the 10 week and further 22 week follow-ups in a repeated measures analysis increases the power to 85% assuming a conservative correlation of 0.8 between all post-baseline measurements and a uniform physiotherapy effect.
For the power analysis, we used the following specifications: a Type I error rate of α =.05, statistical power of.80, a two-tailed test, and a rather conservative correlation between pre and post measurements of 0.5.
Because the standard deviations for the mean changes were not available, these data were estimated from the standard deviations for the pre-treatment and post-treatment measurements as recommend by Cochrane Collaboration, using a more conservative correlation coefficient (r = 0.4) [ 13, 14].
A conservative intraclass correlation of 0.07 was assumed for clustering at the clinic level.
We applied an LLS cutoff of 2.1 to each protein pair that corresponds to a conservative Pearson correlation coefficient for co-expressed gene pairs of ~0.94.
Based on power analyses and assuming a conservative intracluster correlation coefficient, 1289 children were needed to detect a 25% difference in rates between the two groups of the cluster trial.
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