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The percentages of participants with rSBA titers ≥1 128, a more conservative correlate of protection, were also evaluated [ 48].
In addition, antibody titres were also measured using a threshold of 1 128, which is the more conservative correlate of protection [ 8].
Nevertheless, at 1 month post-vaccination, ≥99.3 % of the children who received MenACWY-TT had rSBA titres ≥1 128 for each of the four vaccine serogroups, which is the more conservative correlate of protection.
The target strains used in the rSBA assays were L10 for serogroup A, C11 for serogroup C, MP01240070 for serogroup W-135, and S-1975 for serogroup Y. rSBA titres ≥8 for serogroup C are considered to predict protection [ 36], and this threshold was extended to the other serogroups as well [ 37]. rSBA titres ≥128, a more conservative correlate of protection, were also evaluated [ 38].
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Conservative results of life forecasting which well correlate with experimental data are received.
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