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The A. nidulans CaM gene is transcribed as a single, 0.85-kilobase mRNA species that encodes a predicted protein 84% identical (93% similar if conservative changes are considered) to vertebrate CaM.
Fourteen amino acid substitutions, all conservative changes, are predicted to result from nucleotide changes in the coding region.
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"The withholding of votes prior to obtaining conservative changes is virtually the only leverage conservatives have at this point, and so they must use it".
At positively selected amino acid sites, non-conservative changes are almost as frequent as conservative changes.
Only one conservative change is detected in the Mγ bHLH domain of D. melanogaster compared with D. virilis, and just two in M5.
The real problem would come if some unacceptable (to the Conservatives) changes were made, because even if the Commons overturned them, the Lords could kill the bill be refusing to accept that, or by offering different changes in lieu.
We found that the changes T155A, D186N, L188D, D207M & D228G represented positions for which a non-conservative change was present only in the axolotl (additional file 1).
She had the backing of the Liberal Democrats, but some senior Conservatives believe that changes are being held up by what they refer to as "regressive attitudes in Downing Street.
(B) Proportion of synonymous and non-synonymous SNPs identified in the coding region of the genome among non-synonymous SNPs (nsSNPs), proportion of conservative and non-conservative homozygous and heterozygous changes are shown.
RBBP4 and RBBP7 are 89.4% identical, and the majority of the amino acid changes are conservative substitutions (Figure 3C, grey boxes).
Thus, we may provide evidence that metabolic rearrangements can happen within a short time period if necessary, whereas proteomic changes are more conservative.
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