Sentence examples for conservative changes from inspiring English sources

Most of the amino acids that form the binding pocket of the FHA domain, those that comprise the FHA/BRCT1 interface, and those that contact phosphorylated residues are precisely conserved or have conservative changes.

At least seven mutations, while non-conserved among PIK3CA orthologs, are conservative changes matching residues in one or more of the three other corresponding human PIK3C paralogs.

It is striking that, unlike for MCT4, all the key binding residues are conserved in MCT2 except for two conservative changes (Leu to Ile and Ser to Ala).

a mRNa length in bp b Start codon position c Stop codon position d ORF length in bp e Protein length in aa A multiple alignment of the Arabidopsis and Clementine proteins with ClustalX exhibited a high degree of conservation between the six proteins, with 627 identical residues, and 142 conservative changes, representing an overall similarity higher than 85%.

Oea has resumed printing, with conservative changes to the staff.

He had invited governors to propose more conservative changes to their Medicaid programs and marketplaces, taken steps to reverse Obama-era rules implementing the ACA and pulled back on experimenting with new ways of paying Medicare providers.

Of these five variants, three were synonymous changes (L18L, S192S, P394P), and two resulted in non-conservative changes (T134M, L347R) in evolutionary conserved amino acids (Fig. 1B, C).

Some of the non-conservative changes will have little effect, depending upon their predicted position in the resulting protein.

Though conservative amino-acid substitutions may have an effect on the underlying protein structure and therefore, virulence, these latter, non-conservative changes have greater potential for affecting the virulence of WY96.

When compared to the wild-type sequence there were several changes in each DNA sequence and these corresponded to both conservative and non-conservative changes in the amino acid sequences.

Our mutagenic analysis employed a series of conservative or non-conservative changes, and so was used to assess the binding phenotypes induced by residues present in other FIV isolates (Figure 5A).