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For our key findings we also report conservative adjustments of the significance levels by using the Bonferroni technique (36 comparisons, Bonferroni-adjusted α level = 0.0014).
We have used conservative adjustments, but these may be warranted so as to minimize undue emphasis on potentially false-positive results.
Due to the large number of tests performed, almost all results would be non-significant if conservative adjustments for multiple testing were applied.
Although the possibility of residual confounding could not be ruled out completely, the associations between vitamins C and E intake were examined under the most conservative adjustments taking into account a large number of likely or known determinants of cataract.
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However, the smallest observed unadjusted p-value of 0.05 would not be significant after correction for multiple testing even if a less conservative adjustment (such as adjusting for the ~7 independent tests once LD is taken into account) were used.
"The decline was primarily due to a conservative adjustment in the fund's holdings of LightSquared, to be consistent with the results of work done by the Fund's third party valuation firm," a Harbinger representative said in a statement.
Gurwith says they did nine substudies based on race, which, with a straightforward, conservative adjustment known as the Bonferroni correction, changes the p value to roughly 0.18.
None of these remained significant after conservative adjustment for the number of performed analyses in each strategy.
The p-value obtained in this analysis is equivalent to the EASE score, which uses a conservative adjustment of the Fisher's exact probability, and was applied to identify significantly enriched gene categories.
The EASE score is essentially a sliding-scale, conservative adjustment of the Jackknife Fisher exact probabilities that strongly penalizes the significance of categories supported by few genes and negligibly penalizes categories supported by many genes, therefore yielding more robust results.
The associations for Asn248Ser and Ser602Ile also persisted when adjusting for covariates (OR for 248Ser: 2.13, 95% CI: 1.16 3.90, p = 0.015; OR for 602Ile: 1.95, 95% CI: 1.10 3.44, p = 0.023) and showed borderline significance after the conservative adjustment for population stratification (p = 0.061 for Asn248Ser and p = 0.064 for Ser602Ile).
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