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The multispecies conservation was defined as follows.
Conservation was defined by the number of genomes that had matches to the same corresponding segment of the genome.
Conservation was defined as the presence of a binding site in three or more species (MacIsaac et al. 2006).
The depth of LCR conservation was defined on the basis of the species in which the LCR was present, using LCR sequence overlap as evidence of conservation.
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Since these test sequences are not uORFs, "conservation" is defined in a way analogous to a small ORF.
Variability metrics are based on information content calculated as Shannon entropy [ 26] and conservation is defined as the frequency of the predominant peptide.
This recognition requires a shift in how 'units' of conservation are defined and considered, from a species-orientated approach to one that includes diversity at both inter- and intra-specific levels.
Conservation is defined as the difference between the maximum possible entropy for a given alphabet (e.g., amino acids) and the observed entropy; hence, conservation of a protein sequence ranges from zero bit (for a random sequence) to approximately 4.32 bit (full conservation).
Affinity co-conservation is defined similarly, but using N C instead of N T. We first calculated the Spearman correlation coefficient ρ using each of the 7626 pairs of TFs.
Because this conservation status was defined by genome position, the conservation status of a given sdSNP was determined uniquely even if multiple transcripts included the exon flanking the sdSNP (Processes 6 and 7 in Figure 2).
The conservation rate was defined as the number of motifs conserved in a species divided by the number of motifs observed in the human genome.
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