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Despite their evolutionary conservation, the physiological role of mammalian Cdc14 phosphatases is poorly understood.
Despite the low level of overall sequence conservation, the physiological functions of the C. elegans protein with regard to proPC2 appear to be similar to those of the vertebrate proteins.
Interestingly, despite their ubiquitous expression and high conservation, the physiological function of flotillins is far from clear and their role in the endothelium has, to our knowledge, not yet been determined.
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JEB carried out the conservation analysis, created the physiological models, constructed the single gene phylogenies, and drafted the manuscript.
In addition, the conservation of physiological and disease pathways between C. elegans and humans provides a particularly suitable research platform to advance our understanding of NP action on human health.
In 1993, a second study showed that the physiological water-conservation ability did not differ between Namib Desert Horses and other populations when dehydrated for periods of up to 60 hours, but suggested that the Namib Desert Horse would show improved conservation ability when dehydration periods were extended to upwards of 72 hours, a common occurrence in their feral state.
This finding is intriguing in respect of the assumed conservation of physiological function of PUM proteins for germ-cell development and neurogenesis, suggesting that analogous phenotypes may be accomplished by targeting related mRNAs that are part of the same regulatory network.
The presented quantitative pharmacological data underlines the evolutionary conservation of GPRC6A to the rat and signifies the physiological importance and emerging pharmacological potential of GPRC6A.
The same approach could also be used to integrate conservation in many other practices, such as finding the physiological complex of a crystal structure and scoring docking results.
Network structural conservation across physiological scenarios coupled with the successful empirical validation of our approach suggested that in silico network perturbations can predict in vivo qualitative responses.
The physiological significance of intron insertion site conservation will be discussed later.
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