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Despite the sequence conservation, the functional role of this protein varies between different bacterial species.
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Table 5 illustrates the relationship between protein conservation and promoter conservation, on the functional category basis.
This significant conservation reveals the functional and evolutionary relevance of the expression context.
The two proteins display the highest conservation in the functional SAF-Box and RNA recognition motif (RRM) domains.
We observed the conservation of the functional domains of the predicted HIRA protein as defined in metazoans (supplementary material Fig. S1A).
Various hypotheses try to explain, or at least to correlate, the evolutionary rate (sequence conservation) and the functional properties of the protein-coding gene.
To get a better insight into the evolutionary need of maintaining so many Egfr ligands, and, at least in fish, two copies of Egfr, we investigated the conservation of the functional domains of the receptor, including the receptor-ligand interface.
Initial evaluation was focused on the evolutionary conservation of the functional domains in OanTERT and included full-length TERT sequences of platypus and seven species representing different vertebrate systematic groups.
Here we want to estimate the percentage of human functional regions conserved in the mouse based on our new conservation measurement and the functional regions mentioned above.
This strong conservation strongly supports the functional importance for these mC sites in roles such as regulating the structure and stability of rRNAs and tRNAs [ 2].
This high conservation rate confirms the functional importance of non-coding sequences in Theileria, which goes beyond a role as passive intergenic spacers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com