Because of the lack of phylogenetic conservation, the functions of most, if not all, CT-X antigens, both in gametogenesis and tumorigenesis, remain poorly understood.
Thus, for this domain also, a conservation of the function is reflected in sequence conservation.
Although orthologization and evolutionary conservation of PK protein sequences has been well established, little is known about evolutionary conservation and the function of non-coding DNA sequences of PK genes.
To determine if there is a relationship between gene block conservation and the function of the gene blocks, we assigned each operon keywords based on its function.
This is the first study to address and demonstrate a possible conservation of the function of Dock1 in the clearance of dead cells in mammals.
Our analyses also revealed that nearly all of the paralogous and orthologous extensin-pairs have been under strong purifying selection, leading to the strong conservation of the function of extensins duplicated from the same ancestral gene.
Evolutionary conservation of the function of Yae1 and Lto1 is shown via the demonstration that their function in yeast can be replaced by the human orthologues YAED1 and ORAOV1.
We identified 14 orthologous pairs of POP-like proteins across the two plant species, suggesting high degree of conservation in the function of POP-like proteins across the two species (See additional file 4: Table S4.pdf).
In trypanosomes, we found that a modest knockdown of ARL6 does not kill the parasite but causes a significant decrease in flagellum length, suggesting some evolutionary conservation in the function of this protein.
We have previously shown some degree of conservation in the function of some Dlx CREs between mouse and zebrafish but it is not clear when these CREs and their associated regulatory mechanisms originated during vertebrate evolution [ 16, 17].
