Sentence examples for conservation signals from inspiring English sources

RENULL helps in subtracting these background conservation signals but can allow us to select only the residues which are important for family-wide-function [8].

Hence, it appeared that cancer mutations in protein kinases may not display strong sequence conservation signals and consequently, functional importance of kinase genetic variants may not be directly related with their evolutionary conservation.

calcium binding proteins, RNA binding proteins, tyr-kinases/phosphatases and guanine nucleotide exchange factors also had strong conservation signals.

Although bidirectional promoters are orthologous between humans and mice, they exhibit sparse conservation signals in multi-species alignments.

We restricted our analysis to these parts, since we cannot de-convolute the conservation signals for the protein-coding exons for the other areas.

Scoring functions that may be better suited to detect other types of conservation signals can be plugged into the INTREPID framework to obtain improved predictions.

(B ) Attribution of the conservation signal to the confounding effects of conserved regions.

The 40 bp method may also detect some short sequences provided they have a strong enough conservation signal (e.g. a highly conserved GC-rich transcription factor binding site).

Although at first glance this finding might seem at odds with the elevated evolutionary conservation of chimera-identified non-canonical sites (Grosswendt et al., 2014), we found that this conservation signal was not smaller for the sites of less conserved miRNAs and therefore was not indicative of functional miRNA binding.

Although kinase cancer mutations may not exhibit a strong sequence conservation signal, we have identified a number of structurally equivalent positions within the protein kinase catalytic core can be frequent targets of tumorigenic mutations.

Most other functional protein classes had little conservation signal.