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On the other hand, constitutive non-CES exons are more frequent in the low conservation range than constitutive CES exons, which are more frequent in the high conservation range.
As shown in Table 1, there are totally 54 958 residues from 496 domains that fall within the residue conservation range of 30 100%.
A number of studies have attempted to predict disease genes computationally using features such as sequence length, paralogy, sequence conservation, range of tissue expression, amino-acid composition and splicing signals among others [ 2, 4, 5, 30].
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There are some clear exceptions within the overall conservation, ranging from a small BES containing only ESAG7 and a VSG, to a BES containing ESAG duplications and triplications.
In particular RrgB is more similar to backbone subunits of S. agalactiae pilus islands 1 and 2a [28] and to serotype M4 S. pyogenes backbone protein Spy0116 [11], where the level of sequence conservation ranges from 36 to 44% of sequence identity.
Epitope conservation ranged from <5% of known HIV viruses for the motif recognized by mAbs such as 268 to 87% for the motif recognized by mAbs such as 3074 (Table 2).
These distributions show that alternative exons are overrepresented in the high and low conservation ranges with respect to constitutive exons.
The conservation ranges from biphasic mode of hematopoiesis to signaling molecules crucial for progenitor cell formation, maintenance, and differentiation.
Although the other three genomes showed a conservation of clusters in the range of 43 80%, conservation ranged from 20%to26%6% in Me. pennsylvanicum.
Depending on the USUV strain, the nucleotide sequence similarity ranged from 81%to98%8%, whereas amino acid sequence conservation ranged from 94.7% to 99.2% of pairwise identity (Table 1).
At the amino acid level, predicted SRF members exhibit variable degrees of conservation ranging from 32.5 % identity to 77.9% identity (Table 2) and fall into distinct subclades [ 7].
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