Examination of its multiple alignment revealed a conserved NC-H-DxQ signature, which is reminiscent of the conservation pattern seen in papain-like peptidases [ 53, 71, 72].
A similar conservation pattern is observed in other metabolic maps classified as moderately functionally conserved, such as the pathway for glycerophospholipid metabolism (00564).
The conservation pattern of this residue in eukaryotic sequences suggests that at least three of the seven eukaryotic beta-type subunit branches should be proteolytically inactive.
This conservation pattern suggests a possible role in specificity.
Conservation pattern of insulin receptor family was also determined [38].
Pair-wise analysis of DDI conservation revealed a 'sliding conservation' pattern between the evolutionarily neighboring species.
We also assessed the conservation pattern for these variants using multiple alignments of nine different mammalian mitochondrial sequences.
The position-specific conservation pattern is more efficient in identifying conditional exons than the overall conservation score of individual exons.
Of the conserved DDIs, about 63% are found only in two species corroborating the 'sliding conservation' pattern explained above.
However, IRS3L was excluded from the analysis since the software was not able to predict the conservation pattern accurately.
This 'sliding conservation' pattern of DDIs along the evolutionary path is expected because domain evolution is thought to be the primary evolutionary force for speciation [33].
