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Despite very low sequence similarity, the four-helix bundle structure and the conservation of three histidine residues in DUF1572 and additionally conserved residues in the active site are indicators of metal-dependent hydrolase function (Fig. 5a and b).
For the autocatalytic formation of isopeptide cross-links, a conservation of three amino acids including Asn, Lys, and a catalytically important acidic Glu (or Asp) residue are responsible.
The +51 region showed a striking conservation of three GATA and other TF binding sites (Figure S6).
The KSHV LANA sequence in Region II, 41LQPRRKH47, positionally corresponding to the 40ARKRRKG46 RFHVMn motif, had a minimal conservation of three of the five basic residues "RRK" (Fig. 1).
The sequence-based alignments suggested conservation of three acidic residues (Alam et al, 2008).
It also exhibits weak similarity to rusticyanin including conservation of three out of its four critical copper binding residues.
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Ueta, M. et al. Conservation of two distinct types of 100S ribosome in bacteria.
And what an achievement it is: three years in the plotting, in the wake of half a century's conservation of six baroque beds, four of which were royal beds of state.
Each woodpecker filled a unique role in the cavity web and all are important for conservation of two mammal and three bird species that used their cavities.
Another goal is to work on the conservation of seven of the world's river basins, including the Rio Grande, Yangtze, Mekong and Danube — all of them sites of major environmental concerns besides supplying water for Coca-Cola.
The dimerization specificity, the expression pattern, and the conservation of two residues specific for a MyoD bHLH domain suggest that JellyD1 is related to an ancestral MyoD gene.
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