Sentence examples for conservation of target from inspiring English sources
We conclude that programs of vegetation restoration should base upon a range of approaches that include passive restoration, active restoration with a variety of tree and shrub species, and mixed models to conciliate agricultural production, vegetation restoration and conservation of target species.
Germ cell-expressed genes and somatic cell-expressed genes evolve at different rates, and we speculate that the greater conservation of somatic factors would require a correspondingly greater conservation of target sites whereas more rapidly evolving germ cell factors might coevolve with rapidly changing regulatory sites.
In the past few years, complementarity between miRNA and the 3'-UTR of target mRNAs, the conservation of target 3'-UTR sequences across different species, and the thermodynamics of the miRNA MREs were widely used as the criteria to predict MREs in different computational algorithms, including miRanda [34], [37], TargetScan [31], DIANA-microT [32], and RNAhybrid [35].
The most commonly used filtering approach is to look for cross-species conservation of target sites.
Based on sequence conservation of target regions, these assays should detect all known HeV and NiV isolates.
Different miRNA-target prediction algorithms predict targets with different techniques and criteria including base pairing, target accessibility and evolutionary conservation of target site.
As conserved protein protein interaction interfaces are biologically compelling targets for drug discovery (Kozakov et al. 2011), the higher conservation of targets localizing inner cellular compartments might be regarded as a clue for new drug binding.
Our analysis suggests that the explicit evaluation of the effects of game management on other species is rare but warranted, offering opportunities to advance ecological understanding and conservation of both target and non-target species.
Several prediction algorithms have been developed to overcome this difficulty by ascribing different weights to key parameters, such as binding energy between target and miRNA, conservation of the target site, quality of the "seed pairing", et cetera [ 11].
It is conventional to screen for conservation of the target site in majority of target-prediction databases like TargetScan, miRanda, etc.
The miRanda algorithm is based on sequence complementarity between the mature miRNA and its target site, binding energy for the miRNA-target duplex, and the evolutionary conservation of the target site sequence and position in aligned UTRs of homologous genes found in human, mouse and rat [41].
