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The motif is present in pyruvate kinase from diverse species (Fig. 5A) and thus notifies the conservation of phosphorylation site of pyruvate kinase in multiple species.
Incorporating the conservation of phosphorylation motifs across related species into the model might also increase its specificity by adding additional biological restraints.
Conservation of phosphorylation sites.
(B ) Conservation of phosphorylation sites in bZIP63.
Determining the evolutionary conservation of phosphorylation sites requires mapping the experimental data onto protein sequences that are stably mapped onto genomes.
The eukaryotic study by Boekhorst et al. (29) compared the phosphoproteome of six different species, and concluded that the conservation of phosphorylation sites between species is higher than expected by chance, indicating functional relevance.
Similar(54)
Requiring positional conservation of the phosphorylation sites yielded 26 unique phosphorylation sites, which were mapped to 19 common domain models (same PSSM-ID) across all 3 organisms.
These observations indicate the conservation of the phosphorylation motif in PykA from prokaryotes to eukaryotes.
We found conservation of the phosphorylation sites among various species.
Sequence analysis of platypus H2AFX shows conservation of the phosphorylation site at serine 139.
(49) These findings prompted us to assess the conservation of the phosphorylation sites among XRCC4 orthologs.
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