We investigated the sequence conservation of the over-represented putative TFBSs across human, mouse and rat to examine how many of these sites are potentially functional (see Materials and Methods for details).
Yet the extent of amino acid sequence conservation of these genes over all phyla has only been partially examined.
The possibility to obtain a reliable numerical model is relevant also from the point of view of the seismic risk assessment, which is a crucial issue to ensure the conservation of heritage over the centuries.
This illustrates the conservation of function over sequence, as the amino acid conservation of this region is low within each of the four families and, therefore, the entire order.
The latter two sequences also exhibit strong conservation of sequence over the entire length of the region.
Moreover, the functional conservation of apyrase over geological time lends support to the possible use of apyrase as a vaccine candidate throughout the Mediterranean region.
The conservation of operons over vast evolutionary timescales, despite high genome rearrangement rates and very frequent horizontal transfer, and the dependency of operon conservation on biologically relevant traits suggest that natural selection drives the evolution of operons.
To investigate the sequence conservation of snoRNAs over the course of primate evolution, we plotted the sequences of 64 rhesus monkey snoRNA families against those of eight other primate genomes.
The results of variance statistics analysis of cyanobacterial genomes including Prochlorococcus, Synechococcus, and Anabaena indicated that the conserved genes are classified into several groups called "virtual linkage groups (VLGs)" according to their positional conservation of orthologs over the genomes analyzed.
Such significant conservation of TEs over different plant families suggests that TR-GAG elements could also be subjected to events of horizontal transfer like LTR-retrotransposons (Fortune et al. 2008; Roulin et al. 2008, 2009).
