Sentence examples for conservation of functionality from inspiring English sources

As this absence of a signal peptide or a transmembrane region appears incongruous and hardly compatible with the conservation of functionality, the assembly and annotation of the concerned genomes may require a re-examination [ 58].

It has been suggested that if the splicing site of a particular intron coincides at the same amino acid position among members of a group of orthologous proteins, then there is ancient relatedness and conservation of functionality for that amino acid residue [ 47- 50].

Resulting biomolecule-label conjugates need to be investigated in terms of conservation of biomolecule functionality, stability issues and completeness of labelling.

Another bottleneck for the employment of elemental labelling is the conservation of biomolecule functionality and the stability over the whole experiment regarding sample preparation, degradation and/or generation of intermediate products, storage or chromatographic separation [32,90,91].

Moving from the evidence that - despite lack of translation - sequence conservation of pseudogenes suggests functionality, the authors proposed them as perfect endogenous competitors of their ancestral genes, because they retain many of the miRNA binding sites.

Gene duplication during evolution has given rise to both increased functionality through diversification of homologous genes and increased potential for rescuing the effects of deleterious gene mutation through conservation of cellular function.

The species-specific effects of PPARα agonists on hepatocyte proliferation and associated hepatocarcinogenesis were ascribed to a number of factors including properties intrinsic to the PPARα protein, conservation and functionality of PPREs in the promoter of target genes, and presence or absence of co-regulators depending on the cellular environment [18].

Accuracy in genome annotation depends on successful integration of the information provided by computational gene-prediction methods, by pre-existing annotations of closely related genomes, by gene conservation, and by evidence of functionality and expression (Koonin and Galperin, 2003; Madupu et al., 2010; Pati et al., 2010).

Many computational algorithms rely on evolutionary conservation, often considered a hallmark of functionality, to search for target sites likely to be more biologically relevant.

Conservation of the apparent crucial functionality of the duplicates outweighs processes that lead to neofunctionalizaton.

Conservation of such events implies functionality, maybe by regulating the protein level [ 8, 12- 14].