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Indeed, if we compare a group of broadly expressed genes with a group of narrowly expressed genes, with similar high conservation of expression, the latter will always have higher dE E values (and lower dE Z values).
This can be interpreted as the conservation of expression of these gene functions, which are rarely differentially expressed.
Taken together, these results suggested that the ancestral mkrn gene was preferentially expressed in the gonads in a primitive vertebrate, with conservation of expression pattern after duplication in fish and amphibians but partial relaxation of this specificity and possible extension of functions in birds and mammals.
However, the key question is whether the conservation of expression patterns of network constituents necessarily means conservation of functional network interactions.
Since in bilaterians a neural expression of GSX genes is also observed [15], [69] [70], [76] [78], GSX is the only Hox-extended gene group showing clear conservation of expression characteristics between cnidarians and bilaterians.
However, the key question is whether the conservation of expression patterns of network constituents implies conservation of functional network interactions, and if so, how an increased functional complexity can evolve.
This incomplete conservation of expression suggests either subtle differences in the transcriptional machinery between A. stephensi and A. gambiae or that the upstream region chosen lacked all the control elements.
Similar(4)
Comparison of lineage-specific gene expression revealed similar conservation of gene expression patterns.
Moreover, cross-species comparison of ESCs revealed an overall conservation of miRNA expression patterns, indicating stabilizing selection on miRNA expression in ESCs during evolution.
Remarkably, comparison with previous expression profiling of human mammary epithelial cell subtypes showed conservation of gene expression patterns between the two species.
To overcome these limitations, indirect comparisons of gene expression across species have become a popular method for assessing conservation of gene expression.
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