Sentence examples for conservation of effect from inspiring English sources
These data demonstrate the system is effective for comparing the behavior of different organisms of varying shapes (for example, to compare nootropic compounds in multiple species to show conservation of effect across clades and rule out or identify species-specific effects).
To determine conservation of effect in organ regeneration, models of both physical (partial hepatectomy) and chemical (acetaminophen) liver injury were used.
Finally, preclinical studies using human umbilical cord blood cells in vitro and in xenotransplantation demonstrated both safety of use with human cells and strong conservation of effect (Goessling et al., 2011).
After screening ~2500 compounds, this study revealed a number of relevant HSC regulators, including prostaglandin E2 (PGE2) (discussed in more detail below) and nitric oxide (NO) (North et al., 2009), both of which showed strong conservation of effect in vitro and in vivo across vertebrate species, in developmental regulation and organ regeneration.
The comparison of the expression profiles and the tissue distribution of the transcripts show some conservation of effects across the conditions, transcriptome platforms (Affymetrix vs. Nimblegen) and wheat cultivars used (we used Recital; Laudencia-Chingcuanco et al. [ 33] used Bobwhite, and Wan et al. [ 5] used Hereward).
For example, a conservation of major effect loci is generally implied in comparisons of medically relevant traits between mice and man.
QTL synteny blocks that are conserved across all three species (i.e., AS-4q/AC-20/RT-9q AS-22/AC-12/RT-15p-15p) provide the supportst support for the conservation of QTL effects in salmonids.
Understanding the mechanisms of transgenerational phenotypic plasticity affecting health and life span, the conservation of these effects among taxa and the diversity of outcomes between genders are critical to understanding the origins of aging and to developing treatments for age-related diseases.
These findings were also replicated in E13.5 rat cultures (comparable in age to mouse E11.5), demonstrating conservation of the Wnt5a effect across species (data not shown).
Despite conservation of the vasoactive effects of NO in the zebrafish (North et al., 2009), it was found not to be the mechanism of action for liver modulation.
