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The conservation of correlation between the transcript level (i) and the protein level (ii) sheds light on the processes underlying transcription, translation and regulation.
LNS revealed considerable conservation of correlation structure between the two species' expression networks.
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The evolutionary conservation of the correlation between expression divergence and protein divergence suggests that it is the result of long-term selection.
We then perform new gene expression experiments to test for conservation of phenotype-expression correlations across different diets and populations.
There can be a variety of reasons for the conservation of sequence (including correlations between 'distant' regions), but the importance to structure and function, and functional linkage between them, underlie such correlations.
This is indeed shown in figure 4: The higher the degree of gene expression conservation, the higher the strength of correlation.
However, despite this conservation, we found that the degree of correlation is inversely related with the phylogenetic distance between the species.
Fig. 2 A is the relief map of position conservation correlation matrix R(con)L×L of PDZ database.
Fig. 2 B is the contour map of position conservation correlation matrix R(con)L×L of PDZ database.
It shows that the evolutionary conservation of the occurrence-preference correlations is due to the conservation of both codon occurrences and motif preferences across species.
We find that local clustering around interactions correlates with preferred evolutionary conservation of the participating proteins; furthermore the correlation between high local clustering and evolutionary conservation is accompanied by a stable elevated degree of coexpression of the interacting proteins.
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