The A&B model we proposed suggests that the age of gene duplication plays an important role in functional compensation between duplicates, while the sequence conservation indicates the likelihood of a duplicate gene actually genetically buffered by other (nonhomologous) genes, as supported by recent double deletions of yeast duplicate pairs [ 29, 30].
For different tests, this may reflect contributions of evolutionary history of the haplotype block yielding similar conservation patterns, or the likelihood that closely linked alleles all lie within an extended regulatory stretch of chromatin with similar epigenetic marks.
The use of finer-scale physical data to support marine reserve design is more likely to result in the selection of reserves that achieve representation at habitat and microhabitat levels, increasing the likelihood that conservation goals will be achieved.
The alignment of selected DEAD box helicases was used to generate a residue wise conservation score using maximum likelihood approach (Jules-Thornton-Taylor matrix).
This can be visualized as a conservation plot of the likelihood ratio that a given nucleotide position experienced relatively faster or slower accumulation of variation over time; the strongest peaks of the conservation plot, that is, regions of low variation, are expected to correlate with functional regions [47].
Correlated expression levels have also been found to increase the likelihood of conservation among fungi.
In other words, in all likelihood, sequence conservation was responsible for the observed cross-hybridization results.
Therefore, correlated expression levels increasing the likelihood of conservation appears to be a universal phenomenon in eukaryotes including plant genomes.
The high degree of sequence conservation further substantiates the likelihood of exon 3b being utilised in an as yet undescribed human mRNA variant.
However, it is still important to predict chemotherapy-responsiveness in terms of selecting patients who will become candidates for successful breast conservation regardless of the likelihood of achieving pCR.
