Sentence examples for conservation interaction from inspiring English sources

We further characterize the central proteome considering gene structures, conservation, interaction networks, pathways, drug targets, and coordination of biological processes.

We identified 5797 instances of a SNP falling within a conserved predicted MRESS based on stringent filtering of conservation and interaction scores predicted by Betel et al [ 21].

We are exploring this property of conservation of interaction as a means to assign protein functions by concentrating on protein-protein interaction (PPI) pairs with similar interacting modular domain patterns.

Another recent study by [ 10] has also measured the coherency of evolutionary conservation of interaction patterns in an integrated network of S. cerevisiae comprising transcriptional and protein-protein interaction data.

Sequence alignment with several FIC motif containing proteins, complemented with homology modeling on the FIC motif containing protein, VbhT of Bartonella schoenbuchensis as the template, showed conservation and interaction of residues constituting the FIC domain.

Recent studies have combined these approaches with the examination of evolutionary conservation and interaction networks to better understand kinase-substrate relationships [12].While such approaches have expanded our knowledge of kinase-substrate relationships, it is clear that many remain unidentified or uncharacterized by current methods.

Recent high throughput experiments with better coverage [ 13, 14] made it possible to reassess the conservation of interaction data.

While the results in these early papers indicated low overlap between species, no attempt was made to generalize observations to address reasons for the lower conservation of interaction data when compared to sequence data conservation.

These proteins were organized into two architectural groups, i.e., monodomain DUFs and modular, and two potential levels of importance in terms of sequence conservation and interaction, i.e., HIC and Non-HIC proteins.

The utility and evolutionary conservation of interaction networks in these and other genetically tractable metazoan organisms is well established, making them powerful models for exploring human biology and disease mechanisms [ 52- 55].

The positive data for protein-protein interactions were taken on the basis of evolutionary conservation of interactions and the number of experimental observations of interactions using the PubMed IDs.