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In the ATP-hydrolysis sites, substantial loss of conservation has been reported in MKKS [ 27] and in BBS12 [ 23].
Moreover, even between Pythium ultimum and P. infestans (fig. 1), a considerable level of gene-order conservation has been reported (Adhikari et al. 2013).
Since positional enrichment (positional conservation) has been reported previously for similar datasets [ 21], the objective of the above analysis was to examine statistical evidence in support of a similar pattern in the present dataset.
The correlation between protein dynamics in terms of effective mobility (EM) and evolutionary conservation has been reported for some enzymes recently (Liu and Bahar 2012), which is consistent with our findings (Fig. 4 above).
In the sea anemone N. vectensis [ 29], as well as in two species of sea snakes [ 33, 34], a very high degree of conservation has been reported within certain toxin families, suggesting the involvement of concerted evolution processes [ 29].
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In our search we also included motifs originally described in other plant species as cross-conservation has been reported for functional cis-elements [ 33].
For example, although sequence conservation is frequently used to identify regulatory elements, ultra-conservation has been reported to identify only a small subset of developmentally related enhancers, specifically, those involved in development of the nervous system [ 18].
This type of conservation phenomenon has been reported previously but to a lesser extent (17 conserved sites), following examination of the 76 common core residues of ~5300 Kabat sequences of antibodies to a full range of different antigen classes [ 53].
This may reflect the lack of sequence conservation which has been reported for Xist [9], [10].
An overall conservation of 33 36% of amino acid sequences between HAs has been reported [34].
Fragmentary conservation of synteny has been reported between map-anchored Prunus sequences and Arabidopsis.
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