Sentence examples for conservation estimation from inspiring English sources

In addition to requiring mutational biases, selection needs to be weak for the complications in conservation estimation to arise.

Because an earlier version of such data had been successfully explored in concentrating on benign with damaging missense variants [ 10], we followed this approach but used the Rate4Site tool [ 22] for higher accuracy of conservation estimation.

Confidence intervals for the conservation scores estimations are calculated and when the number of sequences is small, the confidence interval tends to be large.

In this study, the rate of evolution at each site was calculated using the empirical Bayesian paradigm that was shown to significantly improve the accuracy of conservation scores estimations over the Maximum Likelihood method, in particular when a small number of sequences was used for the calculations [ 53].

Through these two factors, at any one time, the selection of cooperation nodes will affect both the energy conservation and the estimation accuracy.

Our analysis provides the first quantitative estimate of the size of the eastern golden eagle population, and we demonstrate the utility of one approach to use citizen-science data to address a pressing conservation goal population size estimation.

The most useful techniques are based on mass conservation and enable estimation of the time series and mass spectra of OA factors, representing the contributions of hundreds of different chemical species, and which can be associated with different sources and/or processes.

Promoter region conservation was estimated using phastCon scores, based on 17 vertebrate species genome data and using the same approach as for the estimation of novel contig conservation.

Constraint can then be inferred directly by estimating the parameters of the mutation-selection model without the potentially misleading estimation of conservation with respect to a reference sequence.

However, in the search for clinically relevant mtDNA variants, it is useful to rule out those evolutionary fixed, thus limiting variability analyses to few variants, annotated with estimation of conservation and prediction of pathogenicity, to obtain a shortlist of candidates that affect function of the gene/protein.

However, to get a first estimation of pseudogene conservation among strains, we examined the conservation of the pseudogenes identified in the S. cerevisiae reference strain S288C (Additional file 1, Table S1) among 7 other sequenced strains (see Methods).