Due to the complete gene content conservation, differences in transmission efficiency in A. marginale are likely to be ascribed to sequence variation producing variant proteins or affecting gene transcription.
For each UV in BRCA1 we considered differences in zero or one species out of the 10 examined to represent high conservation, differences in two or three species to represent moderate conservation, and differences in four or more species to represent low conservation.
Our evidence suggests that heat conservation differences could in part account for differences among high and low elevation animals in the ability to cope with low temperatures.
However, despite of this general interspecies conservation, genetic differences in the AprX sequence might be responsible for observed inter individual differences in proteolytic capacity and/or the specific activity of these sequence divergent AprX proteases.
We concluded that the PB2, PB1, PA, NP, and M1 proteins of all recorded influenza A viruses, both avian and human, contain sequences of low variability and high conservation despite differences in evolutionary pathway, subtypes, and host species.
The complimentary strand, miRNA-122*, reveals an overall high conservation, however differences in nucleotides do exist among species.
The pan-genome concept has recently been introduced to explore the diversity of a number of bacterial species and found varying degrees of conservation reflecting differences in habitat, evolutionary pressure and gene pool [ 42- 46].
This conservation difference is more significant in the ME group.
While the genes show a high level of conservation, the difference in the mutation rates as shown in Figure 5 is of interest to understanding the development and evolution of wood formation genes within Salicaceae.
Finally, without identifying rare species, it would not be possible to understand the sensitivity of patterns of conservation value to differences in data analysis.
We observed a positive correlation between mappability and conservation with ∼10% differences in mappability between the most conserved and least conserved exons (Kruskal-Wallis rank sum test, P∼0) (Fig. 2D).
