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We define the gene conservation density as follows.
The correlation coefficient between the gene conservation density and the frequency of appearance of the corresponding metabolically redundant mutants is -0.8224 (p-value < 10-10).
The correlation coefficient between the gene conservation density and the frequency of appearance of the corresponding mutants is 0.6826 (p-value < 0.0025).
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Interestingly, it was predicted to be functional in a recent in silico study based on sequence conservation and density of potential transcription factor binding sites [29].
The identification of a correlation between microsynteny conservation and density of disease gene orthologs suggests that additional experimental analysis of mouse genes in highly conserved genomic regions will produce new mammalian disease models by creating mutations in the orthologs of human disease genes.
Results from computational genomics can also be visualized, e.g. base-by-base conservation scores, gene density and repetitive element density.
The scheme extends the standard Chang-Cooper method by providing not only number density conservation, but also energy conservation.
By examining gene content in conserved and divergent genomic regions we found a significant correlation between microsynteny conservation and the density of mouse genes that are orthologous to human disease genes.
The model is based on the principle of mass conservation of coal density layers transported in the jig's bed.
Species density, conservation value, degree of rareness and abundances of red list and rare species increased with presence of adjacent steppe grasslands.
The hydrodynamic equations have the form of a Euler-like system of conservation laws for density, n, momentum, u, and energy, e, in each of the two bands (the band indices are here omitted).
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