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In addition, this conservation cluster lies within that segment of PrP that displays a high structural plasticity [ 56– 56].
The analysis indicated two cross-pathway clusters of divergence - a higher conservation cluster spanning glycolysis, the TCA cycle plus metabolite transport and the components of the NADH shuttle and pyruvate cycle, and a lower conservation cluster comprising respiratory chain proteins and components of the glutathione pathway.
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These profiles could be separated into distinct conservation clusters by a matrix clustering approach.
Significant enrichment of functional classes (taken from the STRING database) in the conservation clusters were identified employing Fisher's exact test in conjunction with a Bonferroni correction for multiple testing (p<0.01) using the R-package.
We analyzed whether the positive relationship between EN and cluster conservation remains significant after excluding non-OBP genes from the 31 conserved clusters.
The gene order and conservation of clusters were manually inspected with the gene cluster alignment results from AntiSMASH website.
For example, a recent computational strategy that relied upon conservation of clusters of motifs, rather than conserved DNA sequence, was able to fine map regulatory SNPs in select GWAS loci (Claussnitzer et al., 2014).
In summary, these results show a high conservation of clustering in insect miRNAs and suggest a higher level of cluster fragmentation in the Drosophila lineage.
"One of the sad things about the Hamptons is that with all the emphasis on land conservation and clustering, no one in the planning departments pays any attention at all to architecture," said Harry Brown, president of the Brown Companies in Manhattan, a real estate investment company.
Based on this hypothesis, we have designed a new nearest-neighbor method for the prediction of protein secondary structures, in which the reliability of each prediction is estimated based on sequence conservation and clustering in the databases of known structures.
A second feature consists in the conservation of clusters of core genes in particular location of the chromosome, across Thermococcales.
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