Consequently, significant deviations from the uniformity in the pattern of sequence conservation in different subgroups can be attributed to differences in effects of selection within these subgroups.
This violation in the conservation principle of pseudo-components can be attributed to the assumptions of the pseudo-component model, which implies that each pseudo-component behaves as a pure component (constant composition, same independent of depletion) while in reality each pseudo-component is a mixture in itself.
The high sequence conservation of EF-Tu and S12 can be attributed to both the need to interact with multiple binding partners and to the intricacy of their functions, which require exquisite sensitivity to the shape of the codon-anticodon pair [ 15], and apparently place strong constraints on numerous areas of the protein, thus preventing drift due to accumulation of mutations.
Nevertheless, our results are in conjunction with some of the earlier studies [ 6, 16] and can be attributed to the conservation of functionally fundamental biological processes.
This can be attributed to higher conservation in genic regions from where CS SSR markers were developed [ 27] as compared to less conserved genomic regions from where Ah SSR markers were developed [ 28].
In addition, the down-regulation of many photosynthesis-related genes during drought stress (Additional file 15 worksheet 2) can be attributed to the conservation of energy for the survival in drought stress.
For instance, the high conservation of flanking sequence downstream of mir-497~195 can be attributed to the presence of an antisense transcript 'c17orf49'.
The success of neuraminidase inhibitors can be attributed to the sequence and structure conservation of neuraminidase in all subtypes of influenza.
This can be attributed to the statistical testing procedure and the conservation ratio we enforce in Proteny.
The region of positive potential, adjacent to the negative ferroxidase site can be attributed to R89 and H47, again variable spots with conservation grade of 3 and 5, respectively (Figure 6A).
