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How Ras-like GTPases contribute to this process is not known at present, and while there are a considerable number of candidate signaling GTPases encoded within the genome, the levels of sequence conservation are low and the predicted complexity of subtended signaling pathways rather simple, suggesting novel and/or divergent pathways are operating [19], [42].
Although lncRNAs are observed in many species, their degrees of evolutionary conservation are low, and some of the human lncRNAs are thought to have arisen solely in primates [ 5].
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For example, although the putative SH2 binding Tyr-SLiM in Histone H3.1 is conserved among sequences from all selected species, their relative conservation was low because of the highly conserved background.
For example, although the two putative SH2 binding Tyr-SLiMs in Histone H3.1 were conserved among sequences from all selected species, their relative conservation was low because of the highly conserved background (see Figure 1A lower panel for a schematic illustration of the background and SLiM specific relative conservation and alignment of Histone H3.1 Y54).
The linker in RPA70 is an example where the dynamic behavior is conserved even when the sequence conservation is low.
The secondary structure of this region (i.e., helix-turn-helix) is conserved in all classical PTPs, including RPTPγ, although amino acid residue conservation is low.
Although sequence conservation is low N-terminal to the cysteine-flanked core domain between both PrP and ZIP, it should be noted that this region is not well conserved even within orthologs of these protein families, thereby potentially masking evolutionary relationships.
Although the P-value of the conservation was low, it was not significant.
Regions where conservation is low and consistency high may be considered prime targets for phylogenetic reconstruction.
Specifically, related sequences were expected to have regions of high conservation, even if global conservation was low.
A putative homologue was also found in the pCLG1 plasmid but the conservation was low there as well.
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